Response of Pediatric Uveitis to Tumor Necrosis Factor-α Inhibitors
نویسندگان
چکیده
منابع مشابه
Anti-tumor necrosis factor-α agents in noninfectious uveitis.
Anti-tumor necrosis factor-α (anti-TNF-α) agents represent a major breakthrough for the therapeutic management of different autoimmune conditions. Noninfectious uveitis may lead to various sight threatening complications. Hence, from extrapolation of the benefit observed in autoimmune systemic diseases, anti-TNF-α agents are widely used in the treatment of noninfectious uveitis. However, their ...
متن کاملResponse of pediatric uveitis to TNFα inhibitors
Purpose Non-infectious uveitis (“uveitis”) is an important cause of visual loss amongst children. Although TNFa inhibitors (anti-TNFa) are increasingly used to treat pediatric uveitis, the outcomes of treatment with these agents have been poorly described. We are studying the largest, and only multicenter, group of patients with pediatric uveitis in order to more precisely estimate the outcomes...
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Objective(s): To observe and determine the effect and mechanism of psoralen on tumor necrosis factor-α (TNF-α)-induced muscle atrophy.Materials and Methods: Three sets of C2C12 cells, including blank control, TNF-α (10 or 20 ng/ml) treatment and a TNF-α (10 or 20 ng/ml) plus psoralen (80 μM) administration were investigated. Cell viabili...
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Tumor necrosis factor (TNF) is considered a major proinflammatory cytokine, affecting various aspects of the immune reaction. All five TNF inhibitors currently available on the market (i.e., etanercept, infliximab, adalimumab, certolizumab and golimumab) are top sellers, although indicated only in autoimmune diseases, including rheumatoid arthritis, Crohn's disease and psoriasis. This article b...
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Background: It has been suggested that inflammation might be implicated in the gestational diabetes mellitus (GDM) complications, including insulin resistance. The aims of the current study were to explore maternal circulating values of TNF-α, adiponectin and the adiponectin/TNF-α ratio in women with GDM compared with normal pregnancy and their relationships with metabolic syndrome ...
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ژورنال
عنوان ژورنال: The Journal of Rheumatology
سال: 2013
ISSN: 0315-162X,1499-2752
DOI: 10.3899/jrheum.121180